Diclofenac sodium + Serratiopeptidase, a combination of NSAID and therapeutic enzyme, is prescribed for the treatment of pain and inflammation, post-traumatic pain, local relief of pain or inflammation, treatment of pain after radical keratectomy, inflammation due to strabismus surgery, post-photo reflective keratectomy pain and renal colic. Diclofenac sodium + Serratiopeptidase are also given for prophylaxis of intra-operative miosis and actinic keratosis.
Diclofenac exerts potent anti-inflammatory, anti-pyretic and analgesic activity by inhibition of cyclooxygenase pathway (COX) and thus inhibits biosynthesis of prostaglandin and other pro-inflammatory mediators of pain pathway.
Serratiopeptidase, a bacterial peptide-cleaving enzyme obtained from Serratia marcescens. Serratiopeptidase is also a potent anti-inflammatory agent that exerts fibrinolytic and anti-edematic property. The therapeutic enzyme reduce inflammation and swelling in the affected area.
After oral/IM or rectal administration, Diclofenac sodium + Serratiopeptidase is rapidly absorbed in the GIT. However, the absorption rate is very slow in enteric-coated formulations. The drug can enter breast milk and synovial fluid after distribution. The plasma protein binding capability of Diclofenac sodium + Serratiopeptidase is about 99%. Diclofenac sodium + Serratiopeptidase is extensively metabolized in the liver and converted into active metabolites. The drug is extensively excreted in urine as glucuronide and sulfate conjugates. The rest of the elimination is via the bile. The terminal half-life of Diclofenac sodium + Serratiopeptidase is about 1-2 hours.
Diclofenac sodium + Serratiopeptidase is contraindicated in patients with active GI bleeding or perforations, asthma, renal or hepatic disorders, hypertension, porphyria, peri-operative pain in CABG surgery patients and bleeding disorders.
Serratiopeptidase is an enzyme having anti-inflammatory, anti-oedemic and fibrinolytic activity and it also acts rapidly on localized inflammation. Serratiopeptidase has been widely used in the treatment of acute pain. Serrapeptase is a proteolytic (protein destroying) enzyme from bacteria native to the digestive system of silkworms. It is the enzyme responsible for dissolving a silkworm’s cocoon.
Traditionally, serrapeptase has been used for its anti-inflammatory properties. Today, it is marketed as a joint health supplement.
Serrapeptase has been found to have the ability to liquefy mucus and reduce bacterial biofilms (reducing bacteria’s ability to stick to surfaces and each other). This means serrapeptase may be able to reduce phlegm buildup, nasal discharge, lung symptoms of cystic fibrosis and help other compounds fight bacteria. Additional research is needed to confirm these effects.
Functioning of Serratiopeptidase
The drug works by improving aggravated circulation in the inflammatory focus by breaking down abnormal exudates and protein by promoting the absorption of the decomposed products through the blood and lymphatic vessels.
Serratiopeptidase tablets also help the elimination of sputum, pus and haematoma. This they do by breaking down the liquefying mucus secretions and fibrin clots. Another major useful action being increased concentration of antibiotics in the focus of infection.
Vatozic-P Tab (ACECLOFENAC 100MG PARACETAMOL 325MG)
Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.
Aceclofenac Rapidly absorbed almost 100% bioavailability peak plasma levels reached about 1.25-3 hours after oral admin.
Aceclofenac >99.7% bound to plasma proteins distributes into synovial fluid. Paracetamol Distributes throughout most fluids of the body.
Aceclofenac Probably metabolised by CYP2C9 average plasma elimination half-life 4-4.3 hours. Paracetamol Mainly metabolised hepatically plasma elimination half-life 1-4 hours.
Aceclofenac About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol Most metabolites are removed in the urine within 24 hours.
Cinnarizine is used to treat problems affecting the inner ear and balance, such as dizziness and sickness. It is also helpful in preventing travel sickness.
Nerves situated inside your ear send messages to your brain with information about your movement. If the nerves in one of your ears send too many, too few, or wrong messages to your brain, it conflicts with the messages sent from your other ear, your eyes, or your body. Your brain then gets confused and this can cause dizziness and a spinning sensation (vertigo), this is what causes you to feel sick.
Travel sickness is caused by repeated unusual movements during travelling. These repeated movements, such as going over bumps or around in a circle, send lots of messages to your brain.
Cinnarizine helps reduce the feelings of sickness and vertigo caused by problems such as these. It is available on prescription, or you can buy it without a prescription at a pharmacy. It can be taken by adults and by children over the age of 5 years.
Before taking cinnarizine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking cinnarizine it is important that your doctor knows
If you are pregnant or breast-feeding.
If you have prostate problems, or have been experiencing difficulty passing urine.
If you have any problems with the way your liver works or with the way your kidneys work.
If you have any of the following conditions increased pressure in your eye (glaucoma), epilepsy, or Parkinsons disease.
If you think you may have a blockage in your intestines.
If you have a rare inherited blood disorder called porphyria.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
How to take cinnarizine
Take cinnarizine exactly as your doctor or pharmacist tells you to. It is usually taken three times daily.
If you are taking cinnarizine to prevent travel sickness, take the first dose two hours before you are due to travel. If you are going on a long journey, you can then take further doses every eight hours if needed. If you are giving cinnarizine to a child, check the label carefully to make sure you are giving the correct dose for the age of your child. Make sure you leave eight hours between each dose.
If you are able, take cinnarizine after a meal or with a snack.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.Paracetamol (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of action of is not known. Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.
Azithromycin 250 Mg Tablets
Azithromycin is an antibiotic that fights bacteria.
Azithromycin is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases.
Azithromycin may also be used for purposes not listed in this medication guide.
You should not use azithromycin if you have ever had jaundice or liver problems when you have previously taken this medicine.
Before taking this medicine
You should not use azithromycin if you are allergic to it, or if
you have ever had jaundice or liver problems caused by taking azithromycin or
you are allergic to similar drugs such as clarithromycin, erythromycin, or telithromycin.
To make sure azithromycin is safe for you, tell your doctor if you have
a heart rhythm disorder or
a history of Long QT syndrome.
This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether azithromycin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.Do not give this medicine to a child younger than 6 months old.
Cefixime 200mg Clav Pot 125mg
Amoxicillin/clavulanic acid is a combination -type used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.
This treats only bacterial infections. It will not work for viral infections (such as common cold, flu).
Cefpodoxime 200 Mg & Ofloxacin Tablets
Ofloxacin(200 Mg)Ofloxacin is used to treat bacterial infections including upper and lower urinary tract infections, lower respiratory tract infections, skin and soft tissue infections and sexually transmitted infections (of urethra and cervix).
Ciprofloxacin 500 Mg
Ciprofloxacin is an in a group of drugs called fluoroquinolones (flor-o-KWIN-o-lones). Ciprofloxacin fights bacteria in the body.
Ciprofloxacin is used to treat different types of bacterial infections. It is also used to treat people who have been exposed to anthrax.Important information
You should not use this medication if you are also taking tizanidine.
You may not be able to use ciprofloxacin if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.
Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles tendon of the heel. This effect may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.
Stop taking this medicine and call your doctor at once if you have sudden pain, swelling, bruising, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.
Ferrous Ascorbate & Folic Acid, a synthetic form of iron and vitamin C is prescribed for pregnant women to prevent spina bifida in an unborn fetus, to improve iron utilization and to prevent folate or iron deficiency anemia.
Ferrous ascorbate is a synthetic form of iron and vitamin C. Iron is recycled by the body and produce erythroid precursor cells. Exogenous administration of folic acid is essential for normal erythropoiesis process. Folic acid is vital for the biosynthesis of purines and thymidylate of nucleic acids. Defective purine biosynthesis due to folate deficiency leads to megaloblastic anemia and macrocytic anemia.
After oral administration, the iron is predominantly absorbed in the upper jejunum and duodenum. About 90% of the administered dose is bound to plasma proteins. The iron as ferrous forms binds with transferrin and transported to the spleen, liver and bone marrow. The GI absorption of iron is very low due to systemic recycling of iron. About 1 mg/day of endogenous iron is eliminated in the urine, skin and feces.
Folic acid is rapidly absorbed in the proximal portion of the small intestine. After oral administration, the Cmax can be achieved within one hour. As tetrahydrofolic acid derivative, folic acid is well-distributed in all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into dihydrofolate and tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine.
Ferrous ascorbate+Folic acid is contraindicated in patients with iron supplements allergy, patients with hemosiderosis, haemolytic anemia, active infections and hemochromatosis.
Other Drug Interactions
Ferrous ascorbate+Folic acid may interact with , diphenylhydantoin, primidone, tetracycline group of drugs, quinolones, penicillamine, L-dopa, methyldopa, bisphosphonates and calcium salts.
Ferrous ascorbate+Folic acid can be taken before or after food intake
Glimepiride stimulates the insulin release from functioning pancreatic β-cells and inhibits gluconeogenesis at hepatic cells. It also increases insulin sensitivity at peripheral target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).Glimepiride + Metformin Adverse Reactions / Glimepiride + Metformin Side Effects
Diarrhoea, vomiting, metallic taste, rash, isolated transaminase elevations, cholestatic jaundice, allergic skin reactions, photosensitivity reactions, leukopaenia, agranulocytosis, thrombocytopaenia, haemolytic anaemia, aplastic anaemia, pancytopaenia, blurred vision.
Potentially Fatal: Lactic acidosis.
Renal and hepatic impairment. Avoid alcohol consumption. Hypoglycaemic episodes.Other Drug Interactions
Concomitant admin with increases Cmax, AUC, and T1/2 of glimepiride. increases the mean AUC of glimepiride. increases the Cmax of metformin.
Potentially Fatal: NSAIDS, salicylates, sulfonamides, chloramphenicol, coumarins, , MAOs, and beta blockers potentiate the hypoglycemic action of glimepiride.
Type 2 diabetes mellitus
Adult: Per tablet contains glimepiride 1 mg and metformin 250 mg or glimepiride 2 mg and metformin 500 mg: Take as directed. Titrate according to response.
Levocetirizine Hydrochloride IP 5 Mg
Levocetirizine is an antihistamine used to relieve allergy symptoms such as wateryeyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.
How to use levocetirizine
Take this medication by mouth with or without food as directed by your doctor, usually once daily in the evening.
If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.
Tell your doctor if your condition does not improve or if it worsens.
Ofloxacin 200 Mg Tablets
Ofloxacin is given to treat a bacterial infection. It is useful for treating infections such as chest infections, urine infections, skin and soft tissue infections, and some sexually transmitted infections. Some infections can be treated with a single tablet, others require a course of treatment lasting a week or so. Ofloxacin works by killing the bacteria which are the cause of the infection.
· If you are pregnant, trying for a baby, or breast-feeding.
· If you are under 18 years of age.
· If you have ever experienced a problem with your tendons, called tendonitis.
· If you have any problems with the way your kidneys work, or if you have a problem with your liver.
· If you have epilepsy or any other condition that causes fits.
· If you have a heart condition, or if you have been told you have an unusual heartbeat.
· If you have a condition causing tired and weak muscles, called myasthenia gravis.
· If you know you have glucose 6-phosphate dehydrogenase (G6PD) deficiency. This is a genetic disorder which causes problems after eating foods such as fava beans.
· If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.How to take ofloxacin
· Before you start taking the tablets, read the manufacturer's printed information leaflet from inside the pack. The manufacturer's leaflet will give you more information about ofloxacin and a full list of the side-effects which you may experience from taking it.
· Take ofloxacin exactly as your doctor tells you to. The usual dose is one 200 mg or 400 mg tablet taken daily. For some types of infection, however, you may be asked to take two doses a day. Read the label carefully to make sure you know what dose is right for you.
· If you are taking one dose a day, it is preferable to take it in the morning. If you are taking more than one dose a day, try to space out your doses - so ideally, take a tablet every 12 hours.
· You can take ofloxacin before or after meals. Many people find it helps to swallow the tablets with a drink of water.